About Conolidine alkaloid for chronic pain
Most not too long ago, it's been discovered that conolidine and the above mentioned derivatives act on the atypical chemokine receptor 3 (ACKR3. Expressed in identical parts as classical opioid receptors, it binds to the wide array of endogenous opioids. In contrast to most opioid receptors, this receptor acts as a scavenger and would not activate